منابع مشابه
Bad Breaks Don't Doom Meiotic Cells
artifi cial chromosome that also harbored the gene’s normal regulatory sequences. Inserted into a cell, this combination produces a more realistic pattern of gene activity, the scientists say. When the scientists blocked Aurora A activation in this way, a squat spindle resulted. Although the cells could divide, mitosis often went awry, and they sometimes split into three daughter cells. With TP...
متن کاملChecking Your Breaks: Surveillance Mechanisms of Meiotic Recombination
Numerous DNA double-strand breaks (DSBs) are introduced into the genome in the course of meiotic recombination. This poses a significant hazard to the genomic integrity of the cell. Studies in a number of organisms have unveiled the existence of surveillance mechanisms or checkpoints that couple the formation and repair of DSBs to cell cycle progression. Through these mechanisms, aberrant meioc...
متن کاملClustering of meiotic double-strand breaks on yeast chromosome III.
In the yeast Saccharomyces cerevisiae, meiotic recombination is initiated by transient DNA double-strand breaks (DSBs) that are repaired by interaction of the broken chromosome with its homologue. To identify a large number of DSB sites and gain insight into the control of DSB formation at both the local and the whole chromosomal levels, we have determined at high resolution the distribution of...
متن کاملHistone methylation sets the stage for meiotic DNA breaks
Covalent post-translational modifications of histones have important functions in transcription, replication, repair, and other aspects of eukaryotic chromosome dynamics. Trimethylation of lysine-4 on histone H3 is enriched at actively transcribed loci in many organisms. The impact of this histone modification on transcription has been extensively studied, but less is known about its effects on...
متن کاملMapping Meiotic Single-Strand DNA Reveals a New Landscape of DNA Double-Strand Breaks in Saccharomyces cerevisiae
DNA double-strand breaks (DSBs), which are formed by the Spo11 protein, initiate meiotic recombination. Previous DSB-mapping studies have used rad50S or sae2Delta mutants, which are defective in break processing, to accumulate Spo11-linked DSBs, and report large (> or = 50 kb) "DSB-hot" regions that are separated by "DSB-cold" domains of similar size. Substantial recombination occurs in some DS...
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ژورنال
عنوان ژورنال: Nature Reviews Genetics
سال: 2016
ISSN: 1471-0056,1471-0064
DOI: 10.1038/nrg.2016.146